ArticleProceedings of the National Academy of Sciences of the United States of America2026
CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.
Xu Huang, Hongyi Chen, Larry Reser, Andres V Reyes, Shou-Ling Xu, Jeffrey Shabanowitz, Donald F Hunt, Tai-Ping Sun
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Xu HuangDepartment of Biology, Duke University, Durham, NC 27708.
Hongyi ChenDepartment of Biology, Duke University, Durham, NC 27708.
Larry ReserDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904.
Andres V ReyesDepartment of Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA 94305.ORCID 0000-0001-8761-802X Shou-Ling XuDepartment of Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA 94305.
Jeffrey ShabanowitzDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904.
Donald F HuntDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904.
Funding
PROTEIN SEQUENCING BY TANDEM MASS SPECTROMETRYR01GM037537 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HUNT, DONALD F · 1987 to 2023
$17.8MStructure and Function Analyses of DELLA Interacting Proteins in ArabidopsisR01GM100051 · NIGMS · DUKE UNIVERSITY · PI SUN, TAI-PING · 2012 to 2021
$2.4MStructural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in PlantsR01GM150029 · NIGMS · DUKE UNIVERSITY · PI Tai-Ping Sun, Pei Zhou · 2023 to 2026
$1.9MThermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600kHHS | NIH (NIH) GM037537HHS | NIH (NIH) GM100051HHS | NIH (NIH) GM150029HHS | NIH (NIH) S10OD030441NIGMS NIH HHS R01 GM037537NIGMS NIH HHS R01 GM100051NIGMS NIH HHS R01 GM150029NIH HHS S10 OD030441NSF (NSF) MCB-2416564
6 · The paper itselfAbstract
Gibberellin (GA) promotes plant growth primarily by triggering degradation of DELLA transcription regulators, yet how DELLA activity is fine-tuned dynamically by phosphorylation independently of proteolysis remains poorly understood. Here, we show that the CDK8 kinase module of the Mediator complex attenuates activity of the
Indexed as
ArabidopsisArabidopsis ProteinsCyclin-Dependent Kinase 8GibberellinsMediator ComplexRepressor ProteinsGene Expression Regulation, PlantPhosphorylationSignal TransductionArabidopsis ProteinsCyclin-Dependent Kinase 8GAI protein, ArabidopsisGibberellinsMediator ComplexRepressor ProteinsRGA protein, ArabidopsisCDK8DELLA-MED15 interactiongibberellin signalingMediator kinase modulephosphorylation of DELLA proteins
Identifiers
PMID42673446
PMCPMC13552186
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