Trial reportNature aging2026
Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial.
Trial report in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02582138 (Sarcopenia and Physical fRailty IN Older People), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sarcopenia and Physical fRailty IN Older People: Multi-componenT Treatment Strategies (SPRINTT)
Who cites it
0 citing papers in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Preserving independence in older adults is a public health priority. Lifestyle interventions can prevent physical disability, but whether their efficacy is influenced by multimorbidity profiles is unclear. In this post hoc analysis of the SPRINTT randomized trial ( NCT02582138 ), we investigated whether the efficacy of a multicomponent intervention (physical activity with technological support and nutritional counseling) differed across multimorbidity patterns. We included 1,199 community-dwelling adults aged ≥70 years with frailty, sarcopenia and two or more chronic conditions. Latent class analysis identified four multimorbidity patterns: unspecific (55%), psychiatric (24%), cardiometabolic (13%) and respiratory (7%). The intervention reduced the overall risk of mobility disability or death (hazard ratio (HR) 0.78, 95% confidence interval (CI) 0.66-0.92). In subgroup analyses, a significant benefit was observed in participants with a psychiatric multimorbidity pattern (HR 0.65, 95% CI 0.47-0.92). Bayesian partial pooling analyses also supported a beneficial effect in the unspecific pattern (HR 0.80, 95% credible interval 0.69-0.93), while estimates for the cardiometabolic and respiratory patterns were imprecise and not statistically significant. The intervention increased the event-free probability at 24 and 36 months and extended the time free from mobility disability or death by 2.09 months overall. Gains were 3.09 months in the psychiatric pattern and 1.99 months in the unspecific pattern, with no meaningful differences observed in the cardiometabolic and respiratory patterns. These findings suggest that the composition of multimorbidity may influence responsiveness to lifestyle interventions and that stratification based on disease patterns could improve the targeting and effectiveness of preventive strategies in older adults.
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Registered trials
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