ReviewMedicine2026
Nasopharyngeal 13-virus PCR panel for the rapid diagnosis of adenovirus corneal ulcer in an infant: A case report and literature review.
Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
rationaleInfantile corneal ulcer is a sight-threatening emergency, with bacterial and traumatic causes being common. Adenovirus (ADV), especially species D, is an under-recognized pathogen in infants. Corneal scraping is often infeasible in this age group, necessitating alternative diagnostic approaches. PATIENT CONCERNS: A 5-month-old full-term twin presented with bilateral photophobia, conjunctival redness, and mucopurulent discharge lasting 10 days. Hand-held slit-lamp examination revealed pseudomembranous conjunctivitis and bilateral shield corneal ulcers measuring 6.7 mm. DIAGNOSES: Corneal culture was negative, and parental consent for scraping was withheld. A nasopharyngeal swab was tested using a 13-virus multiplex real-time polymerase chain reaction panel for viruses, which detected ADV subtype D within 4 hours, confirming the diagnosis of ADV-induced keratitis.
interventionsTreatment comprised topical acyclovir eye drops (8 times/day) combined with levofloxacin gel (3 times/day), along with mechanical removal of pseudomembranes. OUTCOMES: Complete corneal reepithelialization was achieved within 14 days, with no residual sequelae. LESSONS: Nasopharyngeal 13-virus multiplex polymerase chain reaction offers a minimally invasive, rapid, and reliable diagnostic alternative for infantile adenoviral keratitis when corneal sampling is not feasible.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.