SynthesisFrontiers in oncology2026
The impact of different exercise modalities on health-related quality of life in patients with prostate cancer undergoing androgen deprivation therapy: a systematic review and network meta-analysis.
Synthesis in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Androgen deprivation therapy (ADT) for prostate cancer is associated with adverse effects including fatigue, muscle weakness, adiposity, and impaired health-related quality of life (HRQoL). Exercise interventions may mitigate these side effects, but the comparative efficacy of different exercise modalities remains unclear. Purpose: To determine the effects of various exercise programs on HRQoL and physical functioning in prostate cancer patients undergoing ADT, and to provide evidence-based recommendations for clinical practice. Methods: We systematically searched Chinese and English databases (PubMed, Embase, Cochrane Library) from inception to May 2024 for randomized controlled trials. Two independent reviewers performed screening, data extraction, and risk of bias assessment. A network meta-analysis was conducted using StATA 17.0, with mean differences (MDs) and 95% confidence intervals (CI) as effect measures. Interventions were ranked using the surface under the cumulative ranking curve (SUCRA). Findings: 41 RCTs were found in total and comprised 3, 588 participants. Combined aerobic and resistance exercise (AE+RE) was most effective for improving global HRQoL (FACT-P: MD = 7.96, 95% CI: 2.95-12.96). Resistance exercise (RE) ranked highest for increasing lean body mass (MD = 2.79, 95% CI: 0.68-6.31) and muscle strength (lower limbs: MD = 38.03; upper limbs: MD = 6.71). AE+RE was most effective for exercise capacity (6-minute walk test: MD = 51.10). For fatigue reduction, low-to-moderate intensity exercise ranked highest, though between-intervention differences were non-significant. Conclusion: AE+RE is the optimal intervention for improving overall HRQoL and exercise capacity in ADT patients. RE confers superior benefits for muscle strength, while AE is more effective for reducing adiposity. A combined exercise regimen should be recommended as standard care, with individualization based on patient needs. Long-term follow-up studies are warranted. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=420250408942, identifier CRD420250408942.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.