ReviewFrontiers in immunology2026
Insights into vitamin C in musculoskeletal physiology and disorders: mechanisms and translational perspectives.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C (VC) is an essential micronutrient involved in diverse biological processes, including redox homeostasis, energy metabolism, collagen synthesis, epigenetic regulation, and immune modulation. Increasing evidence indicates that VC plays important roles in the musculoskeletal system, which is essential for structural support, locomotion, and systemic metabolic homeostasis. This review provides an integrated overview of current evidence regarding the roles of VC in musculoskeletal physiology and disorders, with a focus on muscle development and regeneration, bone formation and remodeling, and tendon-bone repair. We further discuss the potential involvement of VC in major musculoskeletal disorders (including osteoporosis, osteoarthritis, rheumatoid arthritis, and sarcopenia) and summarize the interactions between VC supplementation and exercise in musculoskeletal health. By integrating findings from cellular, animal, and human studies, this review highlights that current evidence remains strongest at the mechanistic and preclinical levels, whereas direct clinical evidence and translational validation remain limited. These insights may help guide future experimental studies, more rigorous clinical trials, and the development of VC-based strategies for musculoskeletal health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.