ArticleTurkish journal of biology = Turk biyoloji dergisi2026
Probiotic intervention in colorectal cancer: the cytotoxic and apoptotic potential of
Article in Turkish journal of biology = Turk biyoloji dergisi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aim: Failures in the treatment of colorectal cancer (CRC) have increased scientific interest in the potential of the bioactive compounds contained in cell-free supernatants (CFSs) obtained from probiotic bacteria for cancer treatment. The aim in this study was to investigate the effects of CFSs obtained from Materials and methods: Cytotoxic effects on the cell lines were determined by MTT assay. In line with the IC Results: The MTT assay revealed that CFSs exerted a significant cytotoxic effect on cancer cells. Assessments with AO/PI fluorescent staining confirmed the increase in the number of apoptotic cells. Cell cycle analyses showed a tendency for accumulation in the G0/G1 phase and a decrease in the S phase. Furthermore, in cells treated with inactive CFS, proapoptotic genes (Bax, Cas 9, Cas 8, and Cas 3) were significantly increased, while antiapoptotic Bcl-2 gene expression decreased. Conclusion: This study demonstrates that both live and inactivated
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