ReviewJournal of arrhythmia2026
Evaluation of Hemolysis Risk, Renal Function, and Safety Among Two Pulsed Field Ablation Systems: A Systematic Review and Meta-Analysis.
Review in Journal of arrhythmia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the hemolysis risk, renal, and safety outcomes between two pulsed field ablation (PFA) systems. A systematic review and meta-analysis were performed using PubMed, Cochrane, and ScienceDirect databases for all studies comparing circular to pentaspline PFA systems. Pooled markers evaluated included procedural characteristics, haptoglobin, lactate dehydrogenase (LDH), bilirubin, hemoglobin, and creatinine, with glomerular filtration rate (GFR) and safety markers qualitatively discussed. A total of 11 studies were included, comprising 1517 individuals. While differences in procedural, left atrial dwelling, and fluoroscopy times were statistically insignificant between the two PFA systems, the pentaspline system was significantly associated with lower post-procedural haptoglobin levels (SMD: 0.59; 95% CI: 0.25 to 0.93), higher LDH (SMD: -0.87; 95% CI: -1.49 to -0.253), and higher bilirubin levels (SMD: -0.77; 95% CI: -1.13 to -0.42) compared to circular catheters. No significant differences were observed in total hemoglobin levels (SMD: 0.13; 95% CI: -0.17 to 0.44;
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Registered trials
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