Can hydrolyzed silk fibroin derived from

Şule Barman Kakil, Hamdullah Suphi Bayraktar, Okan Soylu, İshak Gökçek, Meryem İlkay Karagül, Zehra Demiray Asoğlu

Abstract read

In one paragraph

Article in Turkish journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Şule Barman KakilDepartment of Ophthalmology, Tayfur Ata Sökmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0000-0002-5750-6825

Hamdullah Suphi BayraktarExperimental Research Application and Research Center, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0000-0003-3400-9292

Okan SoyluDepartment of Ophthalmology, Tayfur Ata Sökmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0009-0002-5315-150X

İshak GökçekDepartment of Physiology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0000-0002-0590-6405

Meryem İlkay KaragülDepartment of Histology and Embryology, Tayfur Ata Sökmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0000-0002-1990-2640

Zehra Demiray AsoğluDepartment of Histology and Embryology, Tayfur Ata Sökmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkiye.ORCID https://orcid.org/0000-0003-3152-3069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: The therapeutic effects of hydrolyzed silk fibroin derived from Materials and methods: A standardized corneal alkali burn was induced in the right eyes of Wistar albino rats using 1 N sodium hydroxide (NaOH). Animals were randomly assigned to six groups: negative control, positive control (PC), hydrolyzed silk fibroin (SF), ozonized gel (O), combined treatment (SF + O), and antibiotic treatment. Topical treatments were administered for 21 consecutive days. Clinical evaluation included assessments of corneal opacity, neovascularization, and epithelial healing. On day 21, corneal tissues were harvested for biochemical analysis of TGF-β, VEGF, and TNF-α levels, as well as for histopathological assessment. Results: Significantly elevated levels of TGF-β, VEGF, and TNF-α were observed in untreated alkali-burned corneas compared with controls (p < 0.001). All treatment groups demonstrated significant reductions in these mediators compared with the PC group (p < 0.001). The SF and O groups showed comparable effects, whereas the SF + O group exhibited the lowest mean VEGF and TNF-α levels among the treatment groups, with no statistically significant difference compared with the antibiotic group (p > 0.05). Histopathological findings were consistent with the biochemical results, demonstrating improved epithelial integrity, reduced inflammatory cell infiltration, and more organized stromal architecture, particularly in the SF + O group. Conclusion: Hydrolyzed silk fibroin derived from

Indexed as

BombyxBurns, ChemicalCorneal InjuriesEye BurnsFibroinsAnimalsCorneaCorneal NeovascularizationDisease Models, AnimalGelsInflammationMaleRatsRats, WistarSodium HydroxideTumor Necrosis Factor-alphaFibroinsGelsSodium HydroxideTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AbiomaterialsBombyx hatayensisChemical corneal injuryneovascularizationVEGF

Identifiers

PMID42677301

DOI10.55730/1300-0144.6372

PMCPMC13528733

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.