ReviewBioresources and bioprocessing2026
Polyhydroxybutyrate (PHB) production from halophiles: a comprehensive review.
Review in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing environmental impact of petroleum-based plastics has intensified the search for sustainable and biodegradable alternatives. Polyhydroxybutyrate (PHB), a microbial polyester from the polyhydroxyalkanoate (PHA) family, has emerged as a promising biopolymer due to its biodegradability, biocompatibility, and thermoplastic qualities that rival those of conventional polymers. Halophilic bacteria have attracted considerable attention among PHB-producing microorganisms because they thrive in hypersaline environments, enabling non-sterile cultivation, reducing contamination risks, and facilitating cost-effective downstream recovery by osmotic cell lysis. This review provides a comprehensive overview of recent improvements in PHB production by halophilic bacteria, covering physiological adaptations, metabolic pathways, substrate usage, fermentation techniques, and bioreactor optimisation. Particular emphasis is placed on the use of agro-industrial residues and waste-derived feedstocks as sustainable carbon sources to reduce production costs and increase circular bioeconomy results. Recent advances in downstream processing, such as green extraction technologies, metabolic engineering, CRISPR-based gene editing, and synthetic biology approaches to increasing PHB productivity, are critically reviewed. Additionally, developments in polymer modification, life cycle assessment, industrial scalability, regulatory frameworks, and potential applications in packaging, agriculture, and biomedical engineering are discussed. Despite significant progress, issues such as process economics, saline wastewater control, polymer brittleness, and large-scale commercialisation remain. Integrating halophilic biotechnology with waste valorisation, green recovery technologies, sophisticated metabolic engineering, and circular biorefinery concepts offers a promising strategy for developing economically and environmentally sustainable PHB production systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.