Evidence map›Paper›PMID 42679023›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The SLC15A4-TASL complex is essential for lupus development in mice.

Ales Drobek, Maeva Delacrétaz, Aliki Vasilakou, Marta Monguió-Tortajada, Léa Bernaleau, Maxime Dubois, Vanja Sisirak, Manuele Rebsamen

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ales DrobekDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.ORCID 0000-0003-1066-9413
Maeva DelacrétazDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.ORCID 0009-0003-4154-5277
Aliki VasilakouCNRS-UMR 5164, Immunoconcept, Bordeaux University, Bordeaux 33000, France.ORCID 0009-0008-9606-3589
Marta Monguió-TortajadaDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.ORCID 0000-0003-2125-0810
Léa BernaleauDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.ORCID 0009-0006-5892-0151
Maxime DuboisCNRS-UMR 5164, Immunoconcept, Bordeaux University, Bordeaux 33000, France.ORCID 0009-0006-1628-0053
Vanja SisirakCNRS-UMR 5164, Immunoconcept, Bordeaux University, Bordeaux 33000, France.
Manuele RebsamenDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.ORCID 0000-0001-6172-4211

Funding

Agence Nationale de la Recherche (ANR) ANR-20-CE15-0004Indo-French Centre for the Promotion of Advanced Research (IFCPAR) 6203-1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 10006249Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 200709
6 · The paper itself

Abstract

Nucleic acid sensing by endolysosomal Toll-like receptors is critically involved in systemic lupus erythematosus (SLE) and related autoimmune diseases. Downstream of TLR7, TLR8, and TLR9, the SLE-associated SLC15A4-TASL complex selectively mediates IRF5 activation, while being dispensable for NF-κB and MAPK pathways. Here, we show that the SLC15A4-TASL signaling axis is broadly required for disease development and pathogenesis across three complementary genetic SLE models, reflecting different etiologies. Genetic ablation of

Indexed as

Lupus Erythematosus, SystemicMembrane Transport ProteinsAnimalsAutoimmunityDisease Models, AnimalFemaleMiceMice, KnockoutSignal TransductionToll-Like Receptor 7Membrane Transport ProteinsSlc15a4 protein, mouseToll-Like Receptor 7autoimmunitySLC15A4SLETASLToll-like receptors

Identifiers

PMID42679023
PMCPMC13552680

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.