Evidence map›Paper›PMID 42681237›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Spinal Cord Regeneration in Xenopus.

Mohamed El Amri, Lydia Ward, Dominique Alfandari, Gerhard Schlosser, Karel Dorey

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed El AmriFaculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, University of Manchester, Manchester, UK.
Lydia WardFaculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, University of Manchester, Manchester, UK.
Dominique AlfandariUniversity of Massachusetts, Amherst, MA, USA.
Gerhard SchlosserUniversity of Galway, Galway, Ireland.
Karel DoreyFaculty of Biology, Medicine and Health, Division of Developmental Biology and Medicine, University of Manchester, Manchester, UK. karel.dorey@manchester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After an injury, adult mammals do not regenerate or repair their central nervous system in general, and their spinal cord in particular, leading to life-long disabilities. However, many aquatic species such as zebrafish, salamanders and frogs, as well as some land reptiles (turtles and lizards) have the remarkable ability to regenerate their spinal cords. In the case of anurans such as Xenopus, this is a transient ability that disappears after metamorphosis, making it an interesting model with accessible regenerative and nonregenerative stages within the same species. Here, we will summarize our current understanding of the mechanisms that underly spinal cord regeneration in Xenopus tadpoles and describe methods to study changes in cellular state after different paradigms of spinal cord injury.

Indexed as

Spinal CordSpinal Cord InjuriesSpinal Cord RegenerationXenopus laevisAnimalsLarvaXenopusSpinal cord, Regeneration, Xenopus, Injury, CNS, Neural progenitor

Identifiers

PMID42681237

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.