ArticleInternational journal of surgery (London, England)2026
Early versus late supplemental parenteral nutrition in gastrointestinal cancer patients undergoing major abdominal surgery: 5-year outcomes from a randomized clinical trial.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03115957 (Early Versus Delayed Parenteral Nutrition in Abdominal Surgical Patients With Nutritional Risk and Initial Enteral Nutrition Intolerance), which is not on this map. Not yet cited in PubMed.
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Early Versus Delayed Parenteral Nutrition in Abdominal Surgical Patients With Nutritional Risk and Initial Enteral Nutrition Intolerance: A Clinical Randomized Trial
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17 authors.
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Abstract
Background: The long-term effects of supplemental parenteral nutrition (SPN) on survival and recurrence in gastrointestinal (GI) cancer patients undergoing major abdominal surgery remain unclear. This study reports the 5-year overall survival (OS) results from the PNASIT randomized clinical trial (RCT), which compared early SPN [initiated on postoperative day (POD) 3] versus late SPN (initiated on POD 8) in patients with GI undergoing major abdominal surgery. Methods: This multicenter, open-label, RCT was conducted at 11 centers in China. From 1 April 2017 to 31 December 2018, a total of 217 eligible patients with nutritional risk (Nutritional Risk Screening 2002) score ≥3) who were undergoing elective major abdominal surgery for GI cancer were enrolled. Patients were randomized into two groups: the early SPN group (E-SPN; Results: Among the 217 analyzed patients [mean (SD) age, 60.4 (12.2) years; 60.4% male; all of Asian ethnicity], the 5-year OS rate was 70.1% (75/107) in the E-SPN group and 66.4% (73/110) in the L-SPN group [hazard ratio (HR), 0.857; 95% confidence interval (CI), 0.535-1.374; log-rank Conclusion: In GI cancer patients undergoing major abdominal surgery, early SPN showed no significant difference in 5-year OS compared with late SPN. The findings do not support the use of early SPN to improve long-term survival in this patient population. Trial registration: ClinicalTrials.gov Identifier: NCT03115957.
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