Eumelanin from the skin of farm-raised giant salamanders promotes coagulation system homeostasis: a nutritional intervention for postoperative hemorrhage.

Haobo Yuan, Yifei Zhang, Ruiqi Gong, Yuting Tan, Hao Han, Ching Yuan Hu

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Haobo Yuan *Shaanxi Provincial Bioresource Key Laboratory, College of Biological Science and Engineering, Shaanxi Province Black Organic Food Engineering Technology Research Center, Shaanxi University of Technology, Hanzhong, Shaanxi, China.

Yifei Zhang *School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang, China.

Ruiqi GongShaanxi Provincial Bioresource Key Laboratory, College of Biological Science and Engineering, Shaanxi Province Black Organic Food Engineering Technology Research Center, Shaanxi University of Technology, Hanzhong, Shaanxi, China.

Yuting TanShaanxi Provincial Bioresource Key Laboratory, College of Biological Science and Engineering, Shaanxi Province Black Organic Food Engineering Technology Research Center, Shaanxi University of Technology, Hanzhong, Shaanxi, China.

Hao HanShaanxi Provincial Bioresource Key Laboratory, College of Biological Science and Engineering, Shaanxi Province Black Organic Food Engineering Technology Research Center, Shaanxi University of Technology, Hanzhong, Shaanxi, China.

Ching Yuan HuShaanxi Provincial Bioresource Key Laboratory, College of Biological Science and Engineering, Shaanxi Province Black Organic Food Engineering Technology Research Center, Shaanxi University of Technology, Hanzhong, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative hemorrhage is a serious problem that impacts patient recovery. While current hemostatic agents are effective, they also pose a thrombosis risk. Therefore, it is critical to develop safe and natural nutritional intervention strategies. Objective: This study examines the regulatory effect of eumelanin from the skin of farm-raised giant salamanders (GS) on coagulation homeostasis and assesses its potential as a dietary supplement for postoperative recovery. Methods: The structure and biosafety of GS eumelanin were analyzed using SEM-EDS and FTIR, along with various other detection methods. Male Wistar rats (114) were used to evaluate coagulation function and for metabolomic analysis. We assessed tail bleeding parameters and coagulation indices at 2 and 24 h after treatment and analyzed intestinal metabolites 2 h after gavage. Results: SEM-EDS analysis reveals that the GS eumelanin has an irregular aggregated structure with Ca Conclusion: This study reveals that GS eumelanin regulates coagulation homeostasis through its nanostructure and intestinal metabolites. Our results provide a nutritional basis for using natural eumelanin as a functional food ingredient to help manage the risk of postoperative bleeding.

Indexed as

Andrias davidianuseumelaninmetabolomicsnutritional interventionpostoperative hemorrhageUHPLC-Q-Orbitrap HRMS

Identifiers

PMID42682585

DOI10.3389/fnut.2026.1896739

PMCPMC13529939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.