Evidence map›Paper›PMID 42682632›Full record

ArticleFrontiers in immunology2026

Single-cell transcriptomic profile unveils distinct immune ecosystems in alcohol- and nonalcohol-associated hepatocellular carcinoma.

Huan Huang, Haotian Chen, Xutao Xu, Shuo Pan, Yuheng Cheng, Junliang Tang, Qiang Wang, Junyue Tao, Lijuan Huang, Renbiao Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Huan Huang *Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haotian Chen *Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xutao Xu *Department of Gastroenterology, Cixi People's Hospital, Wenzhou Medical University, Ningbo, China.
Shuo Pan *Huashan Hospital, Fudan University, Shanghai, China.
Yuheng ChengNanjing Medical University, Nanjing, China.
Junliang TangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qiang WangGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China.
Junyue TaoDepartment of Gastroenterology, the First People's Hospital of Wuyi, Jinhua, China.
Lijuan HuangDepartment of General Practice, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Renbiao ChenDepartment of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chengtao JinDepartment of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hongxia ZhangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanfei FangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Kan WangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qian CaoDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhenzhen WenDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol-associated hepatocellular carcinoma (A-HCC) shows more aggressive progression and has a poorer prognosis than nonalcohol-associated HCC (NA-HCC), but the underlying tumor microenvironment (TME) heterogeneity remains poorly characterized. Here, we performed single-cell RNA sequencing (scRNA-seq) on tumor and adjacent normal tissues from two A-HCC patients, constructing the first single-cell transcriptomic profile of human A-HCC. This dataset was integrated with public NA-HCC scRNA-seq data to compare cellular composition, functional states, and intercellular communication. Both HCC subtypes displayed immunosuppressive TME features, which were significantly more pronounced in A-HCC. Specifically, A-HCC tumors showed greater enrichment of regulatory T cells (Tregs) with enhanced suppressive function, anti-inflammatory macrophage polarization, and more severe CD8

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsTranscriptomeTumor MicroenvironmentGene Expression ProfilingGene Expression Regulation, NeoplasticHumansSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisT-Lymphocytes, Regulatoryalcohol-associated hepatocellular carcinomaimmunosuppressionsingle-cell RNA sequencingTregtumor microenvironment

Identifiers

PMID42682632
PMCPMC13529772

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.