ArticlePNAS nexus2026
Estradiol mitigates lipid accumulation, oxidative stress, apoptosis, and MAPKs activation in NASH rat model with bilateral orchidectomy.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Nonalcoholic steatohepatitis (NASH) is characterized by hepatocyte injury and lobular inflammation driven by lipid accumulation, oxidative stress, and apoptosis. Low testosterone levels are associated with increased steatosis risk, particularly in transgender women undergoing feminization. To investigate the effects of estradiol supplementation and its mechanisms involving lipid metabolism, oxidative stress, apoptosis, and mitogen-activated protein kinase (MAPK) signaling (ERK, JNK, and p38) in testosterone-deficient rats fed a high-fat, high-fructose (HFHF) diet. Twenty-one male Sprague-Dawley rats were randomized into three groups (
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