ReviewFrontiers in cellular and infection microbiology2026
Polysaccharide based biomaterials for advanced wound healing applications.
Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healing a wound is a complex biological process involving hemostasis, inflammation, cell proliferation, and tissue remodeling. Ad interim, polysaccharide based biomaterials have also attracted significant attention in wound healing due to their intrinsic biocompatibility, biodegradability and structural versatility, and ability to actively modulate the wound microenvironment. This review focuses on key polysaccharides, including alginate, chitosan and hyaluronic acid and discusses their roles across different stages of wound healing by correlating material structure with biological performance. The relationship between material structure and biological performance is discussed to understand their therapeutic effects. Recent advances in hybrid biomaterials, ion-coordination strategies, and stimuli-responsive dressings are highlighted for their roles in enhancing antimicrobial activity, promoting angiogenesis, and enabling controlled therapeutic delivery. Special emphasis is also placed on the emerging role of polysaccharide-based biomaterials in combating chronic wound-associated biofilms through disruption of the extracellular polymeric substance matrix, modulation of quorum-sensing pathways, and localized antimicrobial delivery. These multifunctional approaches improve infection control while simultaneously supporting tissue regeneration, thereby addressing one of the principal challenges associated with chronic wound management. The purpose of this review is to look at the impact of the use of these materials on the environment, specifically by looking at both their biodegradability and lessening of our dependency on synthetic polymers, as well as presenting an integrated design framework that links the composition, physicochemical characteristics, and biological demands of biomaterials within a time-based context to provide a rational approach for developing future wound dressings. Despite promising progress, challenges related to reproducibility, scalability, and clinical translation remain significant, underscoring the need for standardized evaluation and interdisciplinary approaches.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.