Evidence map›Paper›PMID 42683369›Full record

ArticleInternational journal of nanomedicine2026

Transcending Nano-Encapsulation: Engineering Campesterol-Loaded Shellac-PLGA Nanosystem for Breast Cancer Therapy Supported by DFT and Molecular Docking.

Hamid Saeed Shah, Samia Ghani, Faisal Usman, Tahir Ali Chohan, Nida Naeem, Riffat Khan, Hassan Ahmad, Usman Nasrullah, Seema Zargar, Tanveer A Wani

Abstract read
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In one paragraph

Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamid Saeed ShahInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.ORCID 0000-0003-4396-5235
Samia GhaniDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.ORCID 0000-0003-3606-0075
Faisal UsmanDepartment of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 66000, Pakistan.
Tahir Ali ChohanInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.
Nida NaeemInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.
Riffat KhanDepartment of Pharmacy, Minhaj University Lahore (MUL), Lahore, 54600, Pakistan.
Hassan AhmadFaculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, 54000, Pakistan.ORCID 0000-0001-5053-5968
Usman NasrullahInstitute of General Pharmacology and Toxicology, Goethe University Frankfurt Am Main, Frankfurt am Main, 60596, Germany.
Seema ZargarDepartment of Biochemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0002-5622-0841
Tanveer A WaniDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to fabricate and characterize shellac (SH)-PLGA coated plant-derived phytosterol, campesterol (CS) nanoparticles (NPs) for breast cancer therapy. Methods: The nanoparticles were prepared using a nanoprecipitation technique and exhibited a mean size of 120.13 ± 10.29 nm, with PDI = 0.0461 ± 0.0028, and surface charge = -29.35 ± 6.07 mV. Results: In vitro percent cell death screening revealed potent anticancer activity of CS-SH-PLGA-NPs against triple-negative breast cancer cells (MDA-MB-231), yielding an IC Conclusion: Taken together, these findings indicate that CS-SH-PLGA-NPs may serve as a promising nanoplatform for the treatment of breast cancer.

Indexed as

Antineoplastic AgentsBreast NeoplasmsNanoparticlesPhytosterolsAnimalsApoptosisCell Line, TumorDensity Functional TheoryFemaleHumansMDA-MB-231 CellsMiceMolecular Docking SimulationParticle SizePolylactic Acid-Polyglycolic Acid CopolymerAntineoplastic AgentsPhytosterolsPolylactic Acid-Polyglycolic Acid Copolymerbreast cancercampesterolDFT analysismolecular dockingnanoparticles

Identifiers

PMID42683369
PMCPMC13532893

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.