ArticleClinical rheumatology2026
Effectiveness and safety of Janus Kinase inhibitors in patients with rheumatoid arthritis, results from a multicenter observational "real-life" GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the "real-life" effectiveness and safety of Janus kinase inhibitors (JAKis) in patients with rheumatoid arthritis (RA) and to analyze the impact of cardiometabolic comorbidities on these outcomes.
methodsPatients with RA treated with JAKis were evaluated for disease activity scores, patient-reported outcomes (PROs), and safety in a 12‑month multicenter observational study conducted within the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale). Patients were grouped and compared according to the presence of type 2 diabetes (T2D), cardiometabolic multimorbidity (defined as the simultaneous presence of two or more among high blood pressure, T2D, and/or dyslipidaemia), and age ≥ 65 years.
results440 patients treated with JAKis were included (82.9% female; mean age 61.0 ± 11.0 years); 41.4% had high blood pressure, 39.0% obesity, 28.4% dyslipidaemia, 14.3% T2D, and 3.2% a history of cardiovascular events. A statistically significant improvement was observed in all disease activity measures and PROs over the follow-up period. These improvements seemed to be not influenced by the presence of T2D, cardiometabolic multimorbidity, or age ≥ 65 years. During follow-up, a cumulative adverse events incidence of 18.9% was reported; these were mostly mild and reversible, with no life-threatening events. Drug discontinuation due to adverse events occurred in 7.7% of assessed patients (34 discontinuations due to adverse events). Safety outcomes appeared to be not significantly affected by T2D, cardiometabolic multimorbidity, or age ≥ 65 years.
conclusionsIn our "real-life" multicenter cohort in patients with RA, JAKis demonstrated effectiveness with an acceptable safety profile despite the relatively short follow-up and the lack of power to assess clinically relevant differences for rare events. The safety profile should therefore be interpreted with appropriate caution. The presence of T2D, cardiometabolic multimorbidity, and age ≥ 65 years did not appear to adversely influence treatment response or safety. Key Points • TJAK inhibitors were effective in reducing disease activity and improving patient-reported outcomes in real-life patients with RA. • Type 2 diabetes, cardiometabolic multimorbidity, and older age did not appear to impair treatment effectiveness of JAK inhibitors in patients with RA. • Most adverse events of JAK inhibitors were mild, reversible, and infrequently led to treatment discontinuation. • These findings may support the use of JAK inhibitors in clinically complex real-life RA populations encountered in daily practice.
Indexed as
Identifiers
42684557What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.