ArticleAnnals of biomedical engineering2026
Evaluation of a Sol-Gel Zirconia-Silver Coating for Titanium Implants: Assessing Biocompatibility, Osseointegration, and Enhanced Short-Term Antibacterial Efficacy.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clarifying the Experimental Unit and the Evidence for Preserved Osseointegration in a Zirconia-Silver Coating Study.Annals of biomedical engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
purposeImplant-associated infections remain a major cause of failure in titanium-based orthopedic devices, often compromising long-term clinical outcomes and necessitating revision surgeries. Surface modification strategies that provide antibacterial protection while preserving osseointegration are therefore highly desirable. The aim of this study was to develop and evaluate a multifunctional titanium surface capable of preventing bacterial colonization without impairing biological integration.
methodsA titanium surface was engineered using sol-gel technology incorporating silver nanoparticles (Solgel_Ti). Antibacterial performance was assessed through microbiological analyses against Staphylococcus aureus, a clinically relevant pathogen in orthopedic implant infections. In vitro biological safety was evaluated by cytocompatibility assays and Ames's mutagenicity test. The in vivo performance of the coating was investigated using a rat femoral implantation model, with implants analyzed after 90 days through histological and histomorphometric assessments to quantify bone-to-implant contact and new bone formation.
resultsSolgel_Ti demonstrated a significant short-term antibacterial effect against S. aureus when compared with uncoated titanium controls. In vitro analyses confirmed a high biological safety profile, showing excellent cytocompatibility and no evidence of mutagenic activity. In vivo evaluations revealed that Solgel_Ti-coated implants supported effective osseointegration, with bone-to-implant contact and new bone formation comparable to those observed for unmodified titanium. No adverse tissue reactions or signs of impaired bone healing were detected.
conclusionThese findings indicate that Solgel_Ti represents a promising dual-functional surface modification strategy that successfully combines antibacterial activity with preserved osseointegration. This approach offers a viable pathway for the development of safe, infection-resistant orthopedic implants with long-term clinical potential.
Indexed as
Identifiers
42684594What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.