ArticleProceedings of the National Academy of Sciences of the United States of America2026
Genetic evidence and cross-species functional characterization implicate
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang, You-Yuan Zhuang, Zhen Wu, Xin-Ran Wen, Angli Xue, Xiao Zhang, Jian Yang and 1 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Fei-Fei Cheng *New Cornerstone Science Laboratory, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China.ORCID 0000-0003-4924-4607 Hao Mou *Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory for Ophthalmic Cell and Gene Therapy, Beijing 100730, China.ORCID 0000-0002-7536-3565 Zhenyu LiuBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory for Ophthalmic Cell and Gene Therapy, Beijing 100730, China.
Chang-Jun ZhangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory for Ophthalmic Cell and Gene Therapy, Beijing 100730, China.ORCID 0000-0002-8846-6408 You-Yuan ZhuangDivision of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Zhen WuDivision of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Xin-Ran WenDivision of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Angli XueInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Xiao ZhangBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory for Ophthalmic Cell and Gene Therapy, Beijing 100730, China.
Jian YangNew Cornerstone Science Laboratory, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China.ORCID 0000-0003-2001-2474 Zi-Bing JinBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory for Ophthalmic Cell and Gene Therapy, Beijing 100730, China.ORCID 0000-0003-0515-698X Funding
Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes JYY2023-6Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes PWD&RPP-MRIBeijing Research Ward Excellence Program BRWEP2024W172050100Chinese Institutes for Medical Research CX23YZ14MOST | National Natural Science Foundation of China (NSFC) 82125007MOST | National Natural Science Foundation of China (NSFC) 92368206MOST | National Natural Science Foundation of China (NSFC) U23A20165"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2022SDXHDX0001"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2024SSYS0032
6 · The paper itselfAbstract
Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the aging population globally. Although genome-wide association studies (GWAS) have identified many AMD susceptibility loci, the genes and mechanisms underlying many of these associations remain unresolved. Here, we integrated expression quantitative trait locus (eQTL) data with AMD GWAS to prioritize nine putative genes. Through in vivo screening in zebrafish, we demonstrated that the downregulation of
Indexed as
Genetic Predisposition to DiseaseMacular DegenerationAnimalsCytoskeletal ProteinsDisease Models, AnimalGenome-Wide Association StudyHumansMiceQuantitative Trait LociZebrafishCytoskeletal Proteinsage-related macular degenerationCNN2photoreceptor degenerationretinal neurovascular homeostasisstatistical genetics
Identifiers
PMID42685076
PMCPMC13552911
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