Evidence map›Paper›PMID 42685086›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Eugene Koo, Gabriella Quinn, Cassie L Behrendt, Brian Hassell, Katie N Kang, Kelly A Ruhn, Gonçalo Vale, Jeffrey G McDonald, Wenhan Zhu, Sebastian E Winter and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2026
5 · Who and what money

Authors and funding

11 authors.

Eugene KooDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Gabriella QuinnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Cassie L BehrendtDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Katie N KangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Gonçalo ValeCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1104-0289
Jeffrey G McDonaldCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Wenhan ZhuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-3771-0842
Sebastian E WinterDepartment of Internal Medicine, Division of Infectious Diseases, University of California Davis School of Medicine, Davis, CA 95616.
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2759-4641

Funding

Tissue Culture & Antibody Production CoreP01HL160487 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Helen Haskell Hobbs · 2022 to 2026
$14.9M
Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9M
INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Central metabolism of Salmonella in the inflamed gutR01AI118807 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Sebastian E Winter · 2015 to 2026
$5.3M
Commensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2M
Commensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4M
Bacterial Regulation of Intestinal Lipid MetabolismF31DK126391 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KOO, EUGENE · 2021 to 2025
$178k
Burroughs Wellcome Fund (BWF) 1017880Crohn's and Colitis Foundation (CCF) 1440322HHMI (HHMI) Investigator SupportHHS | NIH (NIH) F31 DK126391HHS | NIH (NIH) P01 HL160487HHS | NIH (NIH) P30 DK127984HHS | NIH (NIH) R01 AI118807HHS | NIH (NIH) R01 DK070855HHS | NIH (NIH) R01 DK134692HHS | NIH (NIH) R35 GM147470HHS | NIH (NIH) T32 AI005284NHLBI NIH HHS P01 HL160487NIAID NIH HHS R01 AI118807NIAID NIH HHS T32 AI005284NIDDK NIH HHS F31 DK126391NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK070855NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM147470Welch Foundation (The Welch Foundation) I-1874
6 · The paper itself

Abstract

Enteric bacterial pathogens profoundly alter intestinal physiology during infection, yet their effects on host lipid metabolism remain poorly understood. Using mass spectrometry lipidomics, we found that infection of the mouse intestine with the bacterial pathogen

Indexed as

Fatty AcidsIntestine, SmallLipopolysaccharidesSalmonella typhimuriumAnimalsCD36 AntigensEscherichia coliIntestinal MucosaLipid MetabolismMiceMice, Inbred C57BLSalmonella InfectionsCD36 AntigensCd36 protein, mouseFatty AcidsLipopolysaccharidesfatty acidsintestinal epithelial cellslipid metabolismlipopolysaccharideSalmonella Typhimurium

Identifiers

PMID42685086
PMCPMC13552659

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.