Evidence map›Paper›PMID 42685196›Full record

ArticleScience advances2026

Defective EV-mediated transport of SHH alters neural fate specification in EPM1 epilepsy.

Andrea Forero, Veronica Pravata, Fabrizia Pipicelli, Elisa Frenna, Alessandro Soloperto, Marta Ianni, Natalia Abate, Francesco Di Matteo, Zagorka Bekjarova, Laura Canafoglia and 8 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrea ForeroPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0000-0003-0767-9901
Veronica PravataPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0000-0002-0081-9310
Fabrizia PipicelliMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0001-8641-8317
Elisa FrennaPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0009-0008-3280-3007
Alessandro SolopertoMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0002-8142-6059
Marta IanniPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0009-0008-0241-967X
Natalia AbatePhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0009-0004-6797-6507
Francesco Di MatteoMax Planck Institute of Psychiatry, Munich, Germany.
Zagorka BekjarovaMax Planck Institute of Psychiatry, Munich, Germany.
Laura CanafogliaFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-5385-761X
Francesca RagonaFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0003-1399-8271
Giuseppina MaccarroneMax Planck Institute of Psychiatry, Munich, Germany.
Mariano Gonzalez PisfilCore Facility Bioimaging and Walter-Brendel-Centre of Experimental Medicine, Biomedical Center, Ludwig Maximilian University, Munich, Germany.ORCID 0000-0002-5008-8763
Christian Wahl-SchottDivision of Cardiovascular Physiology and Pathophysiology, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.
Filippo M CernilogarDivision of Molecular Biology, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0000-0003-2814-3436
Matthias EderMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0002-2579-2628
Rossella Di GiaimoPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0000-0003-3604-3697
Silvia CappelloPhysiological Genomics, Biomedical Center (BMC), LMU Medizin, LMU Munich, Munich, Germany.ORCID 0000-0003-1553-6775

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular milieu, including extracellular vesicles (EVs), plays a pivotal role in brain development. In this study, we sought to elucidate the pathogenesis of progressive myoclonus epilepsy type 1 (EPM1), a disease caused by mutations in the

Indexed as

Epilepsies, MyoclonicHedgehog ProteinsNeuronsAnimalsHumansMutationOrganoidsProtein TransportSignal TransductionHedgehog ProteinsSHH protein, human

Identifiers

PMID42685196
PMCPMC13537273

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.