Evidence map›Paper›PMID 42685207›Full record

ArticleScience advances2026

A newly established reverse genetic system for a circular RNA virus reveals new requirements for infection and its biocontrol potential.

Yi Guo, Marco Forgia, Nadia Serale, Beatriz Navarro, Virgilio Balmas, Safa Oufensou, Quirico Migheli, Cristina Formiglia, Stefania Daghino, Antonio Prodi and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yi GuoInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0009-0008-9864-5611
Marco ForgiaInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0000-0003-0101-1046
Nadia SeraleInstitute for Sustainable Plant Protection, National Research Council of Italy, Via Amendola 165/A, 70126, Bari, Italy.ORCID 0000-0002-5552-9361
Beatriz NavarroInstitute for Sustainable Plant Protection, National Research Council of Italy, Via Amendola 165/A, 70126, Bari, Italy.ORCID 0000-0001-8981-1018
Virgilio BalmasDepartment of Agricultural Sciences and NRD-Desertification Research Center, University of Sassari, Viale Italia 39a, Sassari, 07100, Italy.
Safa OufensouDepartment of Agricultural Sciences and NRD-Desertification Research Center, University of Sassari, Viale Italia 39a, Sassari, 07100, Italy.ORCID 0000-0003-4766-7251
Quirico MigheliDepartment of Agricultural Sciences and NRD-Desertification Research Center, University of Sassari, Viale Italia 39a, Sassari, 07100, Italy.
Cristina FormigliaInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0009-0001-6979-7877
Stefania DaghinoInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0000-0001-5722-1558
Antonio ProdiDepartment of Agricultural and Food Sciences, University of Bologna, Viale Fanin 40, 40127, Bologna, Italy.ORCID 0000-0002-7221-7271
Simon SchiwekJulius Kühn-Institute, Institute for Plant Protection in Field Crops and Grassland, Messeweg 11/12, 38104 Braunschweig, Germany.ORCID 0000-0001-7897-7100
Federica BonoDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0001-9716-5327
Niccolò MiottiInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0000-0002-7633-4053
Massimo TurinaInstitute for Sustainable Plant Protection, National Research Council of Italy, Strada delle Cacce 73, 10135, Torino, Italy.ORCID 0000-0002-9659-9470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ambiviruses are fungal-infecting circular RNA viruses that uniquely combine viroid-like and viral features, yet the function of their conserved ORF-B protein and their effects on hosts remain unknown, hindered by the lack of a reverse genetics system. Here, we constructed the first infectious cDNA clone of an ambivirus, Fusarium graminearum ambivirus 1 (FgAV1), using a head-to-tail dimer placed downstream of a fungal promoter. FgAV1 was horizontally transmitted via hyphal anastomosis to virus-free

Indexed as

Fungal VirusesFusariumReverse GeneticsRNA, CircularRNA, ViralRNA VirusesOpen Reading FramesPlant DiseasesRNA InterferenceRNA ReplicationTriticumVirus ReplicationRNA, CircularRNA, Viral

Identifiers

PMID42685207
PMCPMC13537239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.