ArticleEMBO reports2026
Regulation of Type VI Secretion Systems of Burkholderia during transition to intracellular lifestyle.
Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
Pathogenic bacteria tightly regulate gene expression in response to environmental cues. In Burkholderia species, the Type VI Secretion Systems (T6SS) mediate interbacterial competition and host cell interactions. Here, we show that B. thailandensis switches from the anti-bacterial T6SS-1 to the anti-eukaryotic T6SS-5 during phagosomal maturation. While T6SS-1 expression persists in the host cells, its assembly progressively declines with increasing T6SS-5 expression. This switch is controlled by the two-component system VirAG as deletion of virA blocks T6SS-5 expression and restores T6SS-1 assembly in host cells. Furthermore, we found that deletion of T6SS-5 membrane complex restores T6SS-1 assembly in host cells. Notably, T6SS-1 activity in host cells induces mitochondrial fragmentation and apoptosis. Our data suggest that Burkholderia has evolved a mechanism to silence T6SS-1 upon host entry to preserve its replicative niche.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.