Evidence map›Paper›PMID 42687880›Full record

ArticleResearch square2026

Leiomodin 1 deficiency promotes lipid accumulation and redirects gene regulatory programs in smooth muscle cells exposed to oxidized LDL.

Sara A Wennersten, Hongxia Wang, J Lee Franklin, Vivek Nanda

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara A WennerstenUniversity of Alabama at Birmingham.
Hongxia WangUniversity of Alabama at Birmingham.
J Lee FranklinUniversity of Alabama at Birmingham.
Vivek NandaUniversity of Alabama at Birmingham.

Funding

The Role of Leiomodin1 in Hypoxic Neovessel MaturationR01HL167861 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Vivek Nanda · 2025 to 2026
$1.4M
The Role of Leiomodin1 in Vascular DiseaseR00HL136865 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NANDA, VIVEK · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL136865NHLBI NIH HHS R01 HL167861
6 · The paper itself

Abstract

The transition of smooth muscle cells (SMCs) from a contractile to a synthetic, lipid-accumulating phenotype is a central driver of atherosclerosis. We previously identified leiomodin 1 (

Indexed as

foam cell-like cellsgene regulatory networksleiomodin 1lipid accumulationphenotypic modulationvascular smooth muscle cells

Identifiers

PMID42687880
PMCPMC13532720

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.