Evidence map›Paper›PMID 42687894›Full record

ArticleNPJ dementia2026

Peripheral blood microarray-based transcriptomic and epigenetic analyses identify immune, inflammation, and metabolic dysregulation in Alzheimer's disease.

Brendan A Mitchell, Isabella Hausle, Sara Smith, Pamela Thropp, Marina Sirota, Duygu Tosun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brendan A MitchellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA USA.
Isabella HausleDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA USA.
Sara SmithDepartment of Medicine, Division of Rheumatology, University of California, San Francisco, CA USA.
Pamela ThroppNorthern California Institute for Research and Education (NCIRE), San Francisco, CA USA.
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, CA USA.
Duygu TosunDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7M
An Integrative Multi-Omics Approach to Elucidate Sex-Specific Differences in Alzheimers DiseaseR01AG060393 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2018 to 2022
$4.1M
NIA NIH HHS R01 AG060393NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Leveraging multi-omics to better understand the molecular signatures and pathways underlying Alzheimer's disease (AD) pathogenesis is critical for early diagnosis and disease modifying interventions. We performed peripheral blood transcriptome (

Indexed as

BiomarkersComputational biology and bioinformaticsDiseasesNeurologyNeuroscience

Identifiers

PMID42687894
PMCPMC13529590

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.