ArticleFrontiers in physiology2026
Characterization of calcium sources and downstream signaling pathways following electrical field stimulation of rodent longitudinal esophageal muscle.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: To explore the mechanisms involved in esophageal body longitudinal muscle contraction induced by electrical field stimulation. Methods: Isometric contractions of esophageal segments from wistar rats in an organ bath were induced by electrical field stimulation (duration 1 s, frequency 1-100 Hz, intensity 30-90 V) before and after application of pharmacological probes to test involvement of muscarinic receptors, Rho kinase, Ca Results: Electrical field stimulation (EFS) induced contractions showed a frequency and intensity-dependent behavior. Based on the effect size, expressed by the Cohen's d, they were insensitive to the muscarinic receptor blocker atropine (1 µM), the Rho kinase inhibitor Y-27632 (10 µM) as well as the inhibitors of Ca Conclusions: Based on our findings with 2-APB, DHBP, and verapamil, extracellular Ca²
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