ArticleJournal of dental sciences2026
Peritumoral bone changes in mandibular gingival squamous cell carcinoma: A prospective radiologic-histopathologic correlation study.
Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Accurate differentiation between tumor invasion and reactive bone response is essential for surgical planning in squamous cell carcinoma (SCC). This prospective study investigated the radiologic-histopathologic correlation of peritumoral bone changes to distinguish malignant invasion from reactive alterations. Materials and methods: Twenty-four patients with SCC involving the mandibular gingiva or retromolar trigone underwent contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI), followed by mandibulectomy. Peritumoral bone was radiologically classified as intact, altered, or infiltrated. Resected specimens underwent cone-beam CT and histopathologic evaluation. Histopathologic classification included: (1) pattern of invasive tumor front (erosive or infiltrative), and (2) type of peritumoral bone change (sclerosis-dominant, fibrosis-dominant, or invasion-dominant). Radiologic and histopathologic findings were correlated, and five-year recurrence and survival rates were analyzed according to histopathologic classifications. Results: Seventeen of 24 patients exhibited intact or altered peritumoral bone on imaging, which corresponded to sclerosis- or fibrosis-dominant types on histopathology. All infiltrated peritumoral bone cases were histopathologically confirmed as invasion-dominant type, indicating tumor invasion. Patients with sclerosis- or fibrosis-dominant types had significantly better five-year overall survival than those with the invasion-dominant type ( Conclusion: Most peritumoral bone changes observed on CT and MRI in mandibular gingival SCC were found to be reactive rather than truly invasive on histopathologic evaluation. Differentiating these changes has prognostic value and helps identify patients with poorer survival.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.