Evidence map›Paper›PMID 42690266›Full record

ReviewInternational urogynecology journal2026

Hysterectomy with Minimally Invasive Sacrocolpopexy Versus Native Tissue Repair for Primary Uterovaginal Prolapse: A Systematic Review and Meta-Analysis.

Joseph A Huffman, Sarah Ashmore, Shihyun Kim, Dheera Samdariya, Pranadeep Reddy, Mackenzie Wood, Kaidi Kang, Jacqueline Zillioux, Cara L Grimes, Ankita Gupta and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in International urogynecology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joseph A HuffmanDepartment of Urology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Sarah AshmoreDepartment of Urology, UCHealth Northern Colorado, Loveland, CO, USA.
Shihyun KimDepartment of Obstetrics and Gynecology, Henry Ford Health, Detroit, MI, USA.
Dheera SamdariyaDepartment of Urology, Jaslok Hospital, Mumbai, India.
Pranadeep ReddyDepartment of Obstetrics and Gynaecology, SMIMS, Kanyakumari, Tamil Nadu, India.
Mackenzie WoodDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Kaidi KangDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jacqueline ZilliouxDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Cara L GrimesDepartment of Obstetrics and Gynecology, Albany Medical College, Albany, NY, USA.
Ankita GuptaDivision of Urogynecology and Reconstructive Pelvic Surgery, University of Louisville Health, Louisville, KY, USA.
Amy SissonCoy C. Carpenter Library, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Catherine A MatthewsDepartment of Urology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA. catherine.matthews@wfusm.edu.ORCID http://orcid.org/0009-0006-2237-6094

Funding

CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
NCATS NIH HHS UM1TR004929
6 · The paper itself

Abstract

introduction and hypothesisSacrocolpopexy (SCP) is regarded as the gold-standard apical suspension procedure for vaginal vault prolapse; however, systematic reviews informing this reputation have largely included post-hysterectomy populations. Comparative evidence for primary uterovaginal prolapse (U-POP) remains limited. We aimed to evaluate failure and retreatment rates after hysterectomy with minimally invasive SCP compared with vaginal hysterectomy and native tissue repair (TVH + NTR).

methodsA systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO CRD420251171050) as part of the 2026 U-POP Global Consensus Conference. MEDLINE and Embase were searched through October 31, 2025. Eligible studies included randomized trials and comparative cohort studies (≥ 30 participants) evaluating hysterectomy with minimally invasive SCP for primary U-POP, with or without a comparator group undergoing TVH + NTR. Outcomes included retreatment and failure. Pooled proportions of outcomes were estimated and between-group differences were evaluated using mixed-effects meta-regression. Study quality was assessed using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.

resultsOf 5262 abstracts and 189 full texts screened, 24 studies met inclusion criteria: 6329 patients underwent hysterectomy with SCP and 681 underwent TVH + NTR. Compared with TVH + NTR, hysterectomy with SCP demonstrated significantly lower retreatment rates (1.59% vs 10.23%, p < 0.0001), subjective failure (5.09% vs 17.55%, p = 0.002), objective failure (6.80% vs 18.16%, p = 0.002), and composite failure (9.23% vs 18.19%, p = 0.005). Certainty of evidence was moderate to low.

conclusionsFor women undergoing surgery for U-POP, hysterectomy with minimally invasive SCP is associated with significantly lower failure and retreatment rates compared with TVH + NTR and thus may be preferred for patients at higher risk of recurrence.

Indexed as

Apical suspensionHysterectomyNative tissue repairPelvic organ prolapseSacrocolpopexyUterovaginal prolapse

Identifiers

PMID42690266

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.