Evidence map›Paper›PMID 42690440›Full record

ArticleJournal of neurology2026

Insomnia symptoms and stress exposure interact in relation to Alzheimer's disease biomarkers.

Jasper Holleman, Ingemar Kåreholt, Manasa Shanta Näsholm, Charlotte Sørensen, Göran Hagman, Malin Aspö, Miia Kivipelto, Alina Solomon, Shireen Sindi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jasper HollemanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden. jasper.holleman@ki.se.ORCID http://orcid.org/0000-0002-3132-4847
Ingemar KåreholtDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Manasa Shanta NäsholmDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Charlotte SørensenDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Göran HagmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Malin AspöDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Miia KivipeltoDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Alina SolomonDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.
Shireen SindiDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37 A - QA32, Solna, 171 64, Stockholm, Sweden.

Funding

H2020 European Research Council 804371Riksbankens Jubileumsfond P21-0173Vetenskapsrådet 2020-02325
6 · The paper itself

Abstract

backgroundSeveral modifiable factors affect Alzheimer's disease (AD) risk. However, evidence on how these factors interact remains scarce, limiting our understanding of their role in AD development. This study aims to assess interactions between chronic stress exposure and insomnia in relation to AD biomarkers beta-amyloid (Aβ

methodsThe present study included 124 memory clinic patients without dementia from the Cortisol and Stress in Alzheimer's disease (Co-STAR) cohort study. Insomnia symptoms, stressful life events (SLEs) and current perceived stress were self-reported via questionnaires, while AD biomarkers were assessed from the cerebrospinal fluid (CSF). Cross-sectional interactions between stress and insomnia in relation to AD biomarkers were examined using linear regression models.

resultsInsomnia and SLEs interacted in relation to Aβ

conclusionsThis study suggests that chronic stress and sleep disturbances exhibit an interactive relationship in their associations with AD pathology, and highlights the need for further research into interactive effects of multiple modifiable risk factors in the development of AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPeptide FragmentsSleep Initiation and Maintenance DisordersStress, Psychologicaltau ProteinsAgedAged, 80 and overBiomarkersCohort StudiesCross-Sectional StudiesFemaleHumansMaleAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAgingAlzheimer’s diseaseBeta-AmyloidInsomniaSleepStress

Identifiers

PMID42690440
PMCPMC13541817

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.