Evidence map›Paper›PMID 42690475›Full record

ArticleMetabolic brain disease2026

Da chuanxiong formula improves vascular remodeling via promoting angiogenesis and vasodilation mediated by PI3K/Akt/eNOS signaling.

Jiale Gao, Tianyu Lou, Beibei Huang, Xiuying Guo, Hao Wu, Jie Liu, Yueting Li, Menghan Feng, Lirong Liu, Hongbin Xiao

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiale Gao *Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0000-0002-7133-9752
Tianyu Lou *Scientific Research Institute of Beijing Tongrentang Co., LTD, Beijing, China.ORCID http://orcid.org/0009-0007-9455-597X
Beibei HuangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0009-0008-7204-8245
Xiuying GuoSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0009-0002-8474-2919
Hao WuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0009-0001-8341-2187
Jie LiuBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0000-0002-3639-2048
Yueting LiBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0000-0001-5262-3750
Menghan FengSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0009-0001-1781-6722
Lirong LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID http://orcid.org/0009-0007-0187-5895
Hongbin XiaoBeijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. hbxiao@bucm.edu.cn.ORCID http://orcid.org/0000-0002-5317-5440

Funding

National Natural Science Foundation of China No. 82173957National Natural Science Foundation of China-Youth Foundation No. 82505078the Fundamental Research Funds for the Central Universities No. 2025-JYB-XJSJJ-016
6 · The paper itself

Abstract

Vascular cognitive impairment (VCI) is a vast disease with chronic cerebral hypoperfusion (CCH) being the major driver. In our previous study, we have verified that Da ChuanXiong (DCX) formula could alleviate VCI, and obviously upregulate the decreased cerebral blood flow, indicating its potential benefits on vascular remodeling. This study aims to explore the pro-angiogenic and vasodilatory effects of DCX formula after CCH injuries, and clarify its pharmacodynamic substances and potential mechanisms. The rat model of CCH was established by bilateral common carotid artery occlusion. CD31

Indexed as

AngiogenesisDrugs, Chinese HerbalVascular RemodelingVasodilationAnimalsMaleNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionVasodilator AgentsDrugs, Chinese HerbalNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktVasodilator AgentsAngiogenesisDa Chuanxiong (DCX) formulaPI3K/Akt/eNOSVascular remodelingVasodilation

Identifiers

PMID42690475

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.