ArticleBiological trace element research2026
Ameliorative Role of fenugreek Oil Against Lead Acetate Trihydrate-Induced Hepatic, Renal and Testicular Injury in Wistar Albino Rats: Insights into Bcl-2 Expression and sodium/potassium balance.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb) is a prevalent environmental toxicant that induces multisystem toxicity, primarily through oxidative stress and apoptosis. Trigonella foenum-graecum L. (fenugreek) seed oil is enriched with bioactive phytoconstituents possessing potent antioxidant and anti-inflammatory properties. Therefore, this study was designed to investigate the protective effect of fenugreek oil against lead acetate trihydrate (PbAc)-induced hepatic, renal, and testicular histopathological damage in Wistar rats, with emphasis on the anti-apoptotic marker (Bcl-2). A total of 40 rats were randomly divided into four experimental groups (10 in each): a control group (CG), a Pb-intoxicated group (PbG) given 50 mg/kg of PbAc daily, a fenugreek oil-protected group (Pb + FOG) co-administered the same PbAc dose plus 250 mg/kg of fenugreek, and fenugreek oil-only group (FOG) receiving 250 mg/kg of fenugreek oil alone. All treatments were administered via oral gavage over a period of four weeks. Histopathological examination of the PbG revealed marked structural alterations in the hepatic tissue (necrosis, cytoplasmic vacuolation, and inflammatory cell infiltration), renal tissue (glomerular shrinkage and tubular degeneration), and testicular tissue (degeneration of the germinal epithelium and Leydig cells) compared to the CG. In contrast, co-administration of fenugreek seed oil in the Pb + FOG partially restored histological architecture of hepatic, renal and testicular tissues compared to the PbG. However, co-administration of fenugreek seed oil in the Pb + FOG significantly upregulated Bcl-2 mRNA expression compared to PbG (0.65 vs. 0.40; P < 0.01). Sequencing analysis of liver samples showed 97.81-100% nucleotide identity with the Bcl-2 mRNA reference sequence. Lead intoxication in the PbG significantly impaired serum biochemical parameters and elevated Na⁺, K⁺, and Pb levels compared to the CG and FOG. Conversely, co-administration of fenugreek seed oil in the Pb + FOG significantly reduced Pb concentration and restored Na⁺/K⁺ levels. In conclusion, concurrent administration of fenugreek seed oil may attenuate PbAc-induced hepatic, renal and testicular histopathological damage in rats. This protectivity effect was associated with the restoration of sodium/potassium balance, and upregulation of Bcl-2 expression. Nonetheless, further mechanistic studies, particularly addressing oxidative stress markers, are required.
Indexed as
Identifiers
42690521What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.