Evidence map›Paper›PMID 42694239›Full record

ArticleNpj gut and liver2026

Cirrhosis severity modulates proteomic and immune landscapes in hepatocellular carcinoma.

Raksha K R Shastry, Adithya Kale, Sui Seng Tee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj gut and liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raksha K R ShastryDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD USA.
Adithya KaleDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD USA.
Sui Seng TeeDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD USA.

Funding

Longitudinal Metabolic Imaging of the Brain in SynucleinopathyR21AG084142 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SON, JUNSEOK, TEE, SUI SENG · 2023 to 2025
$1.3M
Fructose Metabolism as a Biomarker for Monitoring Hepatocellular CarcinomaR21CA245492 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI TEE, SUI SENG · 2020 to 2020
$397k
NCI NIH HHS R21 CA245492NIA NIH HHS R21 AG084142
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) most often arises in cirrhotic livers, yet the biological impact of cirrhosis severity on the tumor proteome remains poorly understood. We performed a quantitative proteomic analysis of 141 HCC tumors from a publicly available mass spectrometry dataset (Xing et al. Cell Reports Medicine, 2023), stratified by cirrhosis severity to delineate fibrosis-related molecular heterogeneity. Principal component analysis revealed substantial overlap between groups, indicating that increasing cirrhosis severity produces incremental rather than global proteomic shifts. Nevertheless, 295 proteins showed significant differential abundance (Hedges'

Indexed as

BiomarkersCancerComputational biology and bioinformaticsDiseasesGastroenterology

Identifiers

PMID42694239
PMCPMC13538045

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.