ArticleFrontiers in immunology2026
Elevated neutrophil extracellular traps formation driven by the HPV-mediated CXCL8-CXCR1/2-ROS-p21 axis promotes the growth and metastasis of cervical cancer.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of neutrophil extracellular traps (NETs) in cervical cancer (CC) progression, particularly their association with human papillomavirus (HPV) infection, remains unclear. Methods: We analyzed public single-cell RNA sequencing data to explore neutrophil heterogeneity in the HPV-associated CC microenvironment and quantitatively assessed NETs in clinical tissues and serum from normal subjects, HPV-negative, and HPV-positive CC patients. Results: Single-cell transcriptomic analysis revealed a characteristic neutrophil subpopulation (N4) in HPV-positive tumor microenvironments, whose gene expression signature is highly correlated with NETs formation capability. NETs were elevated in CC tissues and sera, especially in HPV-positive tumors. High tissue levels of the NETs-specific marker Cit-H3 correlated with larger tumor diameter, deep stromal invasion and poor differentiation. Functionally, NETs promoted proliferation, angiogenesis, invasion and migration of CC cells; Conclusion: The HPV-triggered CXCL8-CXCR1/2-ROS-p21 pathway drives NETs formation that accelerates CC growth and metastasis. Circulating NETs represent a potential prognostic biomarker.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.