ArticleFrontiers in cell and developmental biology2026
Nicotine-induced conditioned place preference involves dynamic changes in DNA methylation and hydroxymethylation in the zebrafish brain.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Modifications of the DNA methylation/demethylation cycle are fundamental for synaptic remodelling in memory-related processes. Cytosine methylation and demethylation marks epigenetically regulate gene expression and play key roles in addiction-like behaviours. DNA methyltransferases (DNMTs) catalyse methylation of DNA-cytosines (5mC), while ten-eleven translocation (TET) enzymes catalyse DNA demethylation to 5-hydroxymethylcytosine (5hmC) and further cytosine oxidations. 5hmC is stable and abundant in neurons and regulates gene expression. We examined whether conditioned place preference (CPP) to nicotine regulates 5mC and 5hmC levels in the zebrafish brain. Levels of TET1 mRNA were upregulated while levels of TET2, GADD45, DNMT, and MeCP2 mRNAs were downregulated in the zebrafish brain trained in the nicotine-CPP task. Levels of the
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