Evidence map›Paper›PMID 42694654›Full record

ReviewFrontiers in immunology2026

TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.

Yulu Wu, Lian Duan, Luyu Zhang, Shuting Wang, Hongmu Yan, Mingyuan He, Tao Wang, Lili Li, Yuan Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yulu WuDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Lian DuanDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Luyu ZhangDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Shuting WangDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Hongmu YanDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Mingyuan HeDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Tao WangDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.
Lili LiDepartment of Child and Adolescent Healthcare, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Yuan GaoDepartment of Forensic Medicine, School of Basic Medicine, Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-enriched immunoreceptor that functions as a central regulator of microglial adaptation by integrating immune surveillance, lipid sensing, metabolic reprogramming, and phagocytic responses in the central nervous system (CNS). Through association with the adaptor protein DAP12, TREM2 activates interconnected signaling networks involving the SYK pathway, PLCγ2-mediated Ca

Indexed as

Central Nervous System DiseasesMembrane GlycoproteinsMicrogliaNeuroimmunomodulationReceptors, ImmunologicAnimalsHumansSignal TransductionMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humancentral nervous system diseasesmicroglianeuroinflammationtherapeutic targetsTREM2

Identifiers

PMID42694654
PMCPMC13540259

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.