ArticleSurgical neurology international2026
Magnetic resonance imaging-based morphometric differences in the normal pituitary gland with functional and nonfunctional pituitary adenomas.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pituitary adenomas (PAs) are common intracranial neoplasms classified as hormone-secreting or nonfunctional. Nonfunctional PAs (NFPAs) typically present at larger sizes and exert greater mass effect on surrounding structures, including the pituitary gland (PG) and pituitary stalk (PS). However, morphological changes of the PG and PS in the presence of PAs remain incompletely characterized. Methods: A retrospective study of 225 patients (142 NFPAs, 83 hormone-secreting PAs) was performed using 1.5T and 3T magnetic resonance imaging. PG and PS measurements were compared using Welch's Results: NFPAs were significantly larger than hormone-secreting tumors across all dimensions, including height, anterior-posterior width, transverse diameter, and volume ( Conclusion: NFPAs demonstrate larger tumor burden and greater mass effect, whereas hormone-secreting tumors are associated with relatively preserved PG morphology. PS structural changes are limited, with transverse diameter emerging as the primary distinguishing feature. These findings may improve preoperative imaging assessment and surgical planning.
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