Evidence map›Paper›PMID 42695923›Full record

ArticleDrug delivery2026

An injectable hydrogel for localized sustained release of artesunate in postoperative fibrosis prevention after glaucoma filtration surgery.

Guangshuang Tan, Lusi Zhang, Tong Wu, Jingyuan Liu, Ying Wu, Manyi Xiao, Cong Wang, Zheng Pan, Shutong Wang, Chunrun Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Guangshuang TanDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Lusi ZhangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Tong WuCollege of Basic Medicine, Beihua University, Jilin, China.
Jingyuan LiuDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Ying WuDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Manyi XiaoDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Cong WangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Zheng PanDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shutong WangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Chunrun ChenDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shanshan ZhuDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Zewei WangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Boyan MaDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Datong XuDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liyang ShiCollege of Biology, Hunan University, Changsha, China.
Bing JiangDepartment of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma filtration surgery (GFS) is the definitive treatment for reducing intraocular pressure in patients with refractory glaucoma. However, postoperative scarring of the filtration tract is a major cause of surgical failure. Although artesunate (ART) exhibits significant antifibrotic efficacy, its clinical application is severely limited by poor solubility and a short half-life. This study designed and developed a new injectable hydrogel cross-linked by collagen and four-armed polyethylene glycol

Indexed as

ArtesunateFibrosisFiltering SurgeryGlaucomaHydrogelsPostoperative ComplicationsAnimalsCollagenDelayed-Action PreparationsDrug LiberationFibroblastsIntraocular PressureMalePolyethylene GlycolsRabbitsTransforming Growth Factor beta1ArtesunateCollagenDelayed-Action PreparationsHydrogelsPolyethylene GlycolsTransforming Growth Factor beta1artesunatefibrosisglaucomaglaucoma filtration surgerySustained-release hydrogel

Identifiers

PMID42695923
PMCPMC13435280

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.