Evidence map›Paper›PMID 42696556›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.

Jory van Thiel, Noah L Dowell, Cara F Smith, Elda E Sanchez, Sean B Carroll

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jory van ThielHHMI, University of Maryland, College Park, MD 20742.ORCID 0000-0002-5187-7342
Noah L DowellHHMI, University of Maryland, College Park, MD 20742.ORCID 0000-0002-2425-6567
Cara F SmithCentre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L35QA, United Kingdom.
Elda E SanchezNational Natural Toxins Research Center, Texas Agricultural and Mechanical University-Kingsville, Kingsville, TX 78363.
Sean B CarrollHHMI, University of Maryland, College Park, MD 20742.ORCID 0000-0002-7839-5458

Funding

Viper Resource Grant at Texas A&M University-KingsvilleP40OD010960 · OD · TEXAS A&M UNIVERSITY-KINGSVILLE · PI Elda E. Sanchez · 2012 to 2026
$9.2M
HHMI (HHMI) NoneNIH HHS P40 OD010960University of Maryland (UMD) Andrew and Mary Balo and Nicholas and Susan Simon Endowed Professorship
6 · The paper itself

Abstract

Evolutionary innovation is a catalyst for the colonization of new environments and the adaptive radiations of major groups. Novel traits typically evolve through the modification of preexisting characters, but the genetic paths underlying their origin have been challenging to trace, and the general requirements for and relative order of different kinds of gene mutations have been difficult to assess. Here, we trace the genomic origins of four procoagulant venom toxins (factor X, factor V, group I phospholipase A

Indexed as

Evolution, MolecularGenomeSnake VenomsVenomous SnakesAmino Acid SequenceAnimalsFactor XGenomicsMolecular Sequence DataMutationPhylogenyFactor XSnake Venomsadaptive radiationcoagulationevolutionary noveltygene co-optionsnake venom

Identifiers

PMID42696556
PMCPMC13578310

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.