ArticleBrain and behavior2026
Roles of Interleukin-31 in Allergen-Driven Cough: Linking Protease-Activated Receptor-2 Activation and Vagal Ganglion Sensitization in a Dermatophagoides farinae-Induced Asthma Model.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic cough, a distressing symptom of allergic asthma, possibly arises from the abnormal activation of airway-projecting sensory neurons. Levels of interleukin (IL)-31, a Th2 cytokine known for its neuronal effects in pruritus, are elevated in allergic disorders; however, its role in asthma-related cough remains unclear. Therefore, in this study, we aimed to determine the mechanism by which IL-31 influences cough-associated neuronal sensitization using a Dermatophagoides farinae (Derf)-induced asthma model.
methodsWild-type (WT) and Il31 knockout (KO) C57BL/6N mice were intranasally administered the Derf extract repeatedly. Lung tissues, bronchoalveolar lavage fluid, and hilar lymph nodes were analyzed via histology, flow cytometry, enzyme-linked immunosorbent assay, and quantitative polymerase chain reaction. Vagal and dorsal root ganglia were assessed via immunofluorescence assay and Ca
resultsProtease-activated receptor (PAR)-2 activity was evaluated using the agonist SLIGRL-NH
conclusionOverall, IL-31 modulated the neuronal, rather than immune, components of allergic asthma by enhancing the PAR-2-dependent excitability of vagal sensory neurons. These findings highlight the IL-31-PAR-2-vagal pathway as the potential mechanism of and therapeutic target for allergen-driven cough.
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