In one paragraphArticle in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
34 authors.
Laura Pena-CousoCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-8665-1618 Sofía VietoVascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6969-3605 Roberto Silva-RojasCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-0349-4283 María Sánchez-DíazCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-8841-3496 Rafael Romero-BecerraCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0003-3935-2647 Cintia FolgueiraCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0003-3803-9149 Leticia Herrera-MelleCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-9630-2219 Raquel Justo-MéndezCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-7648-3550 Silvia CampanarioCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-9942-2179 Georgiana CrainiciucCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-0912-7425 Sandra Martín-SalamancaCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0009-0002-3624-4149 Vera LukesovaDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, CIBERNED, Barcelona, Spain.
Jessica SegalésDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, CIBERNED, Barcelona, Spain.ORCID 0000-0003-3565-0014 Iván BallesterosCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-6246-2353 Macarena de Andrés-LaguilloCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0001-5309-626X Lorena Esteban-MartínezCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-8163-6259 Jorge Alegre-CebolladaCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0003-0542-0170 José A EnríquezCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-3671-2961 Guadalupe Sabio-BuzoCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-2822-0625 Pura Muñoz-CánovesCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-7533-9047 José A Nicolás-ÁvilaCentro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III, Madrid, Spain.ORCID 0000-0002-8301-7216 Funding
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MNIDDK NIH HHS P30 DK098722
6 · The paper itselfAbstract
Removal of cellular waste from the extracellular space is fundamental for tissue health. Because the rate of material ejected by parenchymal cells varies across tissues, we searched for mechanisms that couple waste production and removal. Here, we show that the uptake of parenchyma-released mitochondria by macrophages is prominent across organs that rely on oxidative respiration-including heart, skeletal muscle, and brown adipose tissue-and that macrophage numbers closely align with the mitochondrial activity of each of these organs. We found that the mitochondrial activity of myofibers dictates the abundance of macrophages by modulating colony-stimulating factor 1 (CSF1) availability and the number of CSF1-producing fibroblasts in the tissue. Consequently, inhibition of CSF1-CSF1 receptor (CSF1R) signaling depleted macrophages and collapsed the mitochondrial activity of skeletal muscles. We propose that, by coupling macrophage abundance to the mitochondrial activity of their parenchyma, tissues ensure efficient waste disposal and fitness.
Indexed as
MacrophagesMitochondriaAdipose Tissue, BrownAnimalsFibroblastsMacrophage Colony-Stimulating FactorMiceMice, Inbred C57BLMuscle, SkeletalReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSignal TransductionCsf1r protein, mouseMacrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating Factor
Identifiers
PMID42696609
PMCPMC13633044
What Socratic holds
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