Evidence map›Paper›PMID 42696639›Full record

Trial reportJournal of the International Society of Sports Nutrition2026

Effects of essential amino acid supplementation on musculotendinous recovery following eccentric plantar flexor exercise: a randomized controlled trial.

Ecaterina Vasenina, Janna P Adams, Foresten L Williams, Timothy H O'Connell, Alyssa L Knuppel, Kaileigh E Moriarty, Koki Kuga, Jolie S Savenor, Sean M Lubiak, Lily A Canoy and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ecaterina VaseninaHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.ORCID 0009-0000-2581-3540
Janna P AdamsHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Foresten L WilliamsOPTIV Solutions Consulting, Orlando, FL, USA.
Timothy H O'ConnellHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Alyssa L KnuppelHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Kaileigh E MoriartyHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Koki KugaHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Jolie S SavenorHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Sean M LubiakSchool of Kinesiology & Rehabilitation Sciences, Division of Kinesiology, University of Central Florida, Orlando, FL, USA.
Lily A CanoyHuman Performance Lab, Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, USA.
Jose AntonioExercise and Sport Science, Nova Southeastern University, Davie, FL, USA.ORCID 0000-0002-8930-1058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise-induced muscle damage (EIMD) resulting from eccentric contractions leads to transient impairments in muscle function. Essential amino acids (EAAs) stimulate muscle protein synthesis and may support recovery following damaging exercise. However, limited research has examined the effects of EAAs on muscle function following eccentric plantar flexor exercise. The purpose of this study was to examine the effects of EAA supplementation on indirect markers of muscle and musculotendinous recovery following EIMD.

methodsThirty-six recreationally active males (age: 21.2 ± 2.7 years) were randomly assigned to an EAA group (10 g of EAAs), placebo (10 g of maltodextrin), or control (no supplementation). Supplements were consumed 30 minutes before and immediately after an eccentric plantar flexor protocol (4 × 50 repetitions followed by one set to failure) and during the 72 hours recovery period. Indirect markers of muscle damage were assessed pre-exercise, immediately post-exercise, and 24, 48, and 72 hours post-exercise, consisting of perceived soreness (NPRS), pain pressure threshold (PPT), calf muscle thickness and Achilles tendon thickness (ultrasound), and calf circumference.

resultsThe eccentric protocol elicited responses consistent with EIMD, including increased soreness (

conclusionsEAA supplementation modestly reduced soreness and was associated with faster recovery of muscle swelling but did not influence tendon morphology within 72 hours.

Indexed as

Amino Acids, EssentialDietary SupplementsExerciseMuscle, SkeletalMyalgiaDouble-Blind MethodHumansMalePost-Exercise RecoveryPost-Exercise Recovery TechniquesTendonsYoung AdultAmino Acids, EssentialDOMSEAAEIMDmuscle recoverymuscle soreness

Identifiers

PMID42696639
PMCPMC13552313

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.