ArticleAAPS PharmSciTech2026
Advanced Bisoprolol Oral Liquid Formulations for Flexible Pediatric and Geriatric Pharmacotherapy.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
The increasing demand for oral liquid formulations (OLFs), highlights the need to optimize pharmacotherapy in pediatric and geriatric populations, where swallowing difficulties and dose individualization are critical. One such drug is bisoprolol, a highly selective β1-adrenergic receptor blocker widely used in the management of cardiovascular diseases, for which individualized dose titration is frequently required, particularly in pediatric and geriatric patients. Conventional solid dosage forms often lack the flexibility required, potentially compromising adherence and increasing the risk of medication errors. This study aimed to develop safe, stable, and palatable OLFs of bisoprolol fumarate suitable for individualized dosing. A Quality by Design (QbD)-oriented approach was employed to define the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs), including drug content, pH, and organoleptic properties. Two sets of formulations were prepared: sugar-free drops and syrups, each at two strengths (2.5 and 5.0 mg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.