ArticleFrontiers in oncology2026
Case Report: Fibromatosis-like metaplastic breast cancer: a case with detection of three genetic alterations, accompanied by local recurrence, lymph node metastasis, and distant metastasis.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fibromatosis-like metaplastic carcinoma (FLMC) is defined as a rare histologic subtype of metaplastic carcinoma within the 2019 World Health Organization (WHO) classification framework for breast tumors. We present a case of FLMC demonstrating a notably atypical clinical presentation. A 73-year-old woman presented with a self-detected breast mass. Radiological and pathological evaluations both indicated potential malignancy. Histological examination showed a lesion composed predominantly of spindle cells and displaying an infiltrative growth pattern. Immunohistochemical staining confirmed co-expression of cytokeratin and p63 within the spindle cell component, supporting a diagnosis of FLMC. During follow-up, the patient developed local recurrence along with lymph node and distant metastases, leading to subsequent next-generation sequencing (NGS) to investigate underlying molecular alterations. Through NGS, we identified a deletion mutation in
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