ArticleJournal of traditional and complementary medicine2026
Qingwen Baidu Decoction attenuates acute lung injury via macrophage exosomal miR-146a suppression of alveolar epithelial cell pyroptosis.
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aim: The anti-inflammatory and anti-pyroptosis effects of traditional Chinese medicine Qingwen Baidu Decoction (QBD), as well as the potential involvement of miR-146a from M2 alveolar macrophage exosomes in acute lung injury (ALI) remain uncharacterized. This study aims to explore the mechanism by which QBD attenuates lipopolysaccharide (LPS)-induced ALI and the involvement of alveolar macrophage exosomal miR-146a. Experimental procedure: Mouse models of LPS-induced ALI were treated with QBD and/or antago-miR-146a. Vascular permeability was assessed by wet/dry (W/D) ratio and total protein concentration of broncho-alveolar lavage fluid (BALF). BALF neutrophils were stained with Wright-Giemsa stain and counted. M2 macrophages were assessed by immunofluorescence. The exosomes and alveolar macrophages were isolated from BALF. Alveolar epithelial type Ⅱ cells (AEC-II) were isolated from lung tissues and incubated with the exosomes. TLR-4/NF-κB signaling and pyroptosis proteins were detected by western blotting and flow cytometry. Results and conclusion: QBD treatment attenuated lung damage and enhanced M2 polarization. M2 secreted exosomal miR-146a was increased after QBD treatment. The exosomal miR-146a can be taken up by AEC-II to suppress AEC-II pyroptosis via inhibiting TLR4/NF-κB signaling pathway. Mid-to high-dose QBD increased miR-146a expression, suppressed TLR4/NF-κB signaling, and attenuated ALI
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