ArticleFrontiers in nutrition2026
Sustainability-oriented recovery of antioxidant and ACE-inhibitory low-molecular-weight peptide fractions from
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Tuna by-products are an important and yet underutilized source of bioactive molecules, pointing out the need for innovative blue- and circular-economy-based approaches for their valorization. Fish protein hydrolysate, obtained through enzymatic hydrolysis, are a valuable source of biologically active peptides. Low-molecular-weight (low-MW) peptides derived from fish-byproducts, in addition to their nutritional value, exhibit remarkable health-promoting effects and have a broad potential for industrial applications, including nutraceutical, pharmaceutical, and cosmeceutical. Methods: In the present study we optimized a valuable strategy that combines enzymatic hydrolysis of tuna mixed by-products including heads, bones, skin, connective tissues, viscera and dark muscle, using Alcalase and Savinase, with ultrafiltration through membranes with molecular weight cut-offs of 10, 5, and 3 kDa. The antioxidant and antihypertensive activities of the resulting peptide fractions were evaluated. The amino acid composition of the most biologically active fractions was subsequently analyzed, and their cytotoxicity was assessed using three Results: Our data identified the low-MW peptide fractions as those with the most prominent antioxidant capacity (AOC) and angiotensin-converting enzyme inhibitory (ACEi) activity, without any observed cytotoxic effect Discussion: Our results demonstrate that enzymatic hydrolysis combined with membrane ultrafiltration is an effective and sustainability-oriented strategy for recovering bioactive peptide fractions from tuna by-products.
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