ArticleJournal of traditional and complementary medicine2026
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Background and aim: Experimental procedure: Male C57BL/6 mice were assigned to standard diet, HFD, or HFD with MAL supplementation via drinking water for 12 weeks. Body weight, fat mass, and adipocyte morphology were assessed. Serum adiponectin levels and hepatic AMPK activation were measured. Inflammatory protein markers in liver and adipose tissues were analyzed by Western blot. Results and conclusion: MAL supplementation did not significantly reduce body weight or fat mass, possibly due to insufficient dosing via drinking water. However, MAL significantly reduced adipocyte size, suggesting a shift from hypertrophy to hyperplasia. Serum adiponectin levels were elevated, and hepatic AMPK activation was enhanced, indicating potential improvements in lipid metabolism and insulin sensitivity. Moreover, expression of inflammatory markers such as TNF-α, MCP-1, and IL-6 was reduced in liver and adipose tissue. These findings suggest that while MAL had limited anti-obesity effects under current administration, it exerted notable anti-inflammatory benefits. Further studies using more concentrated supplementation forms are recommended.
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