Evidence map›Paper›PMID 42698560›Full record

ArticleJournal of traditional and complementary medicine2026

Chungmin Chiu, Wenling Cheng, Tatsung Lin, Huiju Chang, Minhui Tseng, Yujun Chang, Shihli Su, Chiaju Lee, Henhong Chang, Chinsan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chungmin ChiuGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 404328, Taiwan.
Wenling ChengVascular and Genomic Center, Institute of ATP, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Tatsung LinVascular and Genomic Center, Institute of ATP, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Huiju ChangCenter of Regenerative Medicine and Tissue Repair, Institute of ATP, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Minhui TsengDepartment of Chinese Pharmacy, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Yujun ChangBig Data Center, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Shihli SuVascular Medicine and Diabetes Research Center, Institute of ATP, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Chiaju LeeDepartment of Neurology, Changhua Christian Hospital, Changhua, 500011, Taiwan.
Henhong ChangGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 404328, Taiwan.
Chinsan LiuGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 404328, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Spinocerebellar ataxia type 3 (SCA3) is the most common form of hereditary cerebellar ataxia. The insulin/insulin-like growth factor 1 (IGF1) system (IIS) has been proposed as a potential target for disease-modifying therapy. Experimental procedure: A randomized, triple-blind, placebo-controlled crossover trial was conducted in 32 patients with SCA3. Participants received AM or placebo for three months, followed by a one-month washout, then crossed over to the alternate treatment. Plasma NfL and IIS-related markers were measured. Twenty-three participants completed the trial. Results and conclusion: Intention-to-treat analysis revealed a modest within-treatment reduction in NfL levels (27.6 ± 10.7 vs. 25.6 ± 9.8 pg/mL,

Indexed as

Astragalus membranaceusClinical trialInsulin/insulin-like growth factor 1 signalingNeurofilament light chainSpinocerebellar ataxia type 3

Identifiers

PMID42698560
PMCPMC13541599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.