Evidence map›Paper›PMID 42698734›Full record

SynthesisFrontiers in pharmacology2026

Natural products as modulators of age-associated gut microbiota dysbiosis: a systematic review of animal models.

Siti Liyana Saud Gany, Nur Fatin Nabilah Mohd Sahardi, Noradliyanti Rusli, Anis Syauqina Mohd Zaffarin, Azraul Mumtazah Razak, Suzana Makpol

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siti Liyana Saud GanyBiochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Nur Fatin Nabilah Mohd SahardiSecretariat of Research & Innovation, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Noradliyanti RusliFaculty of Bioeconomic Food and Health Sciences, Universiti Geomatika Malaysia, Kuala Lumpur, Malaysia.
Anis Syauqina Mohd ZaffarinBiochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Azraul Mumtazah RazakFaculty of Health Sciences, MAIWP International University, Kuala Lumpur, Malaysia.
Suzana MakpolBiochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is increasingly recognised as a microbiota-driven process, with dysbiosis contributing to oxidative stress, chronic inflammation, and cognitive and functional decline. Natural products, long valued in traditional medicine, are emerging as targeted modulators of the gut ecosystem. This systematic review synthesised current evidence on natural product interventions in ageing animal models. Searches of four databases (2000-2024) yielded 762 records, of which 17 studies met eligibility criteria, encompassing naturally aged rodents, D-galactose-induced, genetically accelerated (SAMP8, Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250602174.

Indexed as

ageing modelsgut microbiotahealthy ageingmicrobial diversitymicrobiome modulationmicrobiota-gut-brain axisnatural productsprebiotics

Identifiers

PMID42698734
PMCPMC13541742

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.