Evidence map›Paper›PMID 42698968›Full record

ArticleiScience2026

How past transient viremia shape natural killer cells' antibody-dependent functions in youth with perinatal HIV.

Arianna Rotili, Chiara Pighi, Alessandro Pucci, Alessia Neri, Giuseppe Rubens Pascucci, Nicole Colantoni, Stefania Bernardi, Elena Morrocchi, Federica Betto, Silvia Di Cesare and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arianna RotiliPhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Chiara PighiClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Alessandro PucciClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Alessia NeriPhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Giuseppe Rubens PascucciClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Nicole ColantoniPhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Stefania BernardiInfectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Elena MorrocchiClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Federica BettoClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Silvia Di CesareResearch Unit of Primary Immunodeficiencies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Donato AmodioClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Mathias LichterfeldThe Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Nicola CotugnoClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Paolo PalmaClinical Immunology and Vaccinology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Funding

Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccinesU01AI135941 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PALMA, PAOLO, ROBB, MERLIN L · 2018 to 2024
$6.4M
NIAID NIH HHS U01 AI135941NIAID NIH HHS UM1 AI164566
6 · The paper itself

Abstract

Despite effective antiretroviral therapy, people living with HIV (PLWH) may experience transient viremia episodes, which may impact Natural Killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC). This study aimed to assess ADCC in youth with perinatal HIV compared with healthy controls (HC) and in relation to prior viremia. 22 PLWH were stratified by virological history and assessed during viral suppression. Peripheral blood mononuclear cells were stimulated with HIV

Indexed as

antibody-dependent cellular cytotoxicitynatural killer cellsperinatal HIVtransient viremia

Identifiers

PMID42698968
PMCPMC13542491

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.